Epigenetic therapies are offering a more targeted way to treat some lymphomas by changing how genes are turned on or off ...

Overcoming tumor resistance to chemotherapy drugs has long been a challenge for oncology clinicians and researchers. Now, a new study suggests that blocking a key protein, p300, may force damaged ...

That superhero is a gene called TP53, and for decades scientists have known it as the “guardian of the genome.” In a healthy ...

Some chemotherapy drugs cause more damage to healthy cells than other chemo options do, a new study finds. The researchers have found four new mutational signatures — patterns of DNA damage left by ...

I. Platinum-based therapies induce DNA inter-strand crosslinks (ICLs), which exacerbate genomic instability and impede DNA replication. In BRCA1/2-deficient tumor cells, the repair of these DNA ...

New research shows hydroxyurea reshapes DNA replication in cancer cells, revealing stress responses that may help design ...

Professor Chao Zhang's team at Zhujiang Hospital, Southern Medical University, has developed a novel DNA nanomachine-based drug delivery and release strategy aimed at overcoming chemoresistance in ...

Stanford Medicine pediatric hematologist Agnieszka Czechowicz, MD, Ph.D., has devoted her research career to improving ...

Finding an effective treatment for osteosarcoma, the most common type of bone cancer in children and young adults, has ...