Suppression of neuroinflammation using small molecule compounds targeting the key pathways in microglial inflammation has attracted great interest. Recently, increasing attention has been gained to ...

Lipopolysaccharide (LPS) is an endotoxin that can cause an acute inflammatory response. Nitric oxide (NO) is one of the most important innate immune system components and is synthesized by inducible ...

Conclusion: ET-743 given by either of these two schedules of administration can induce objective responses in a subset of refractory pts with LMS or LPS. Disease control as demonstrated by stable ...