G-protein-coupled receptors (GPCRs) are one of the largest families of cell surface proteins in the human body that recognize hormones, neurotransmitters, and drugs. These receptors regulate a wide ...

GPCRs (G-protein-coupled receptors) represent the largest family of membrane receptors currently targeted by approved drugs. It is estimated that approximately 700 approved drugs target GPCRs ...

The ability to grow stem cell-derived biological tissues, such as skin and other organs, in the laboratory holds promise for applications in areas including wound healing and transplants. However, ...

Scientists have revealed the effect of temperature on water in protein-ligand interactions, providing a way to produce structures for drug discovery that are less biased by freezing artifacts.

The behaviour of a receptor protein can be influenced by the presence of certain lipids in the membrane it is embedded in.

A novel Raman technique measures protein–ligand binding at physiologically relevant conditions in real time. Researchers at the Texas Agricultural and Mechanical University (TX, USA) have developed a ...

BACKGROUND: The disruption of the blood–brain barrier (BBB) is a central pathogenic event in many central nervous system disorders. However, the mechanisms regulating BBB function remain incompletely ...