RAB GTPases and the related ADP-ribosylation factors (ARFs) comprise the largest family of small GTPases, with over 60 members found in humans. Phosphoinositides, which are phosphorylated forms of ...

Proteins of the Ras superfamily of small GTPases regulate a variety of cellular processes such as intracellular transport, cell shape and motility, as well as differentiation and growth 1. For all of ...

Researchers have uncovered the mechanism that switches off the cell transport regulating proteins. They were able to resolve in detail how the central switch protein Rab is down-regulated with two ...

Autosomal dominant missense mutations that hyperactivate the LRRK2 protein kinase are a common cause of inherited Parkinson’s disease and therapeutic efficacy of LRRK2 inhibitors is being tested in ...

Scientists at the University of California, San Francisco (UCSF), have discovered how to target a class of molecular switches called GTPases that are involved in a myriad of diseases—from Parkinson’s ...