A newly developed luciferase-based reporter can detect problems in protein translocation and disulfide bond formation in the endoplasmic reticulum (ER). Inspired by natural mechanisms found in ...

TTUHSC’s Andrey Karamyshev, Ph.D., received a two-year grant from the National Cancer Institute to investigate new approaches to inhibit STAT3, a protein associated with approximately 70% of all human ...

Janelia researchers have uncovered a novel way that two of the structures inside cells-the endoplasmic reticulum (ER) and lysosomes-coordinate the production of proteins, highlighting how interactions ...

Bacillus subtilis has emerged as a pre‐eminent model organism for the study and application of protein expression and secretion, owing to its robust secretory pathways and genetic tractability. Its ...

Patients with non-secretory myeloma, a disease affecting a relatively small number of individuals, can face obstacles including difficulties in receiving a diagnosis, a scarcity of available clinical ...

In eukaryotic cells—found in animals, plants, and fungi—protein synthesis involves more than the simple assembly of amino acids in ribosomes. Nearly one-third of all human proteins must be transported ...