Every second, millions of cells in your body divide in two. In the space of an hour, they duplicate their DNA and grow a web of protein fibers around it called a spindle. The spindle extends its many ...

CELLS in the neural tube are usually said to divide with their spindle fibres oriented parallel to the luminal surface 1. The plane of cleavage is always at right angles to the direction of the ...

Researchers have identified a novel protein that plays a crucial role in the formation of the mitotic spindle, which is essential for correct segregation of a full set of chromosomes to each daughter ...

Berlin, Germany: Abnormalities in the spindles (the bi-polar thread like structures that link and pull the chromosomes during cell division) of human embryos before implantation may be the primary ...

The story of the cell cycle is often told only through the perspective of the chromosomes as they replicate and then divide. This resource beautifully illustrates the role of the cytoskeleton in that ...

For accurate chromosome segregation to occur during mitosis, sister chromatids connect at their kinetochores to bundles of spindle microtubules, known as kinetochore (K) fibres, that originate from ...

When cells divide, chromosomes need to be evenly segregated between daughter cells. This equal distribution of chromosomes is very important to accurately pass on genetic information to the next ...

Researchers from the Mechanobiology Institute (MBI) at the National University of Singapore have shown that cells can attach to the fibrous protein meshwork that surrounds them only if the fibers are ...

In 2000, researchers discovered that mutations that inactivate a gene known as TRIM37 cause a developmental disease called Mulibrey nanism. The extremely rare inherited disorder leads to growth delays ...

Asbestos and other mineral fibers have long been known to induce lung cancer and mesothelioma. However, the primary mechanisms of fiber-induced carcinogenesis still remain unclear. We investigated the ...