Propofol-related Infusion Syndrome (PRIS) is a life-threatening condition characterised by acute refractory bradycardia progressing to asystole and one or more of:

Propofol-related infusion syndrome (PRIS) is a lethal condition characterized by multiple organ system failures. It can occur due to prolonged administration of propofol (an anesthetic) in mechanically …

Propofol infusion syndrome (PRIS) is a rare syndrome which affects patients undergoing long-term treatment with high doses of the anaesthetic and sedative drug propofol.

Risk factors for the occurrence of PRIS include infusion rates > 4mg/kg/h, prolonged continuous infusion > 20-hours, carbohydrate depletion, catecholamine administration, severe stress, glucocorticoid use. …

Feb 5, 2024 · Aside from propofol dose, other risk factors for PRIS include critical illness, use of vasopressors and steroids, starvation or malnutrition, and subclinical mitochondrial disease.

Apr 30, 2024 · Propofol-related infusion syndrome (PRIS) is a rare but severe condition associated with the administration of propofol, an anesthetic commonly used for sedation in medical procedures. …

If PRIS is suspected, propofol should be discontinued and an alterna-tive sedative agent initiated. General measures to support cardiac and renal function should be initiated promptly in patients with …

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Propofol-related infusion syndrome (PRIS) is a rare but potentially fatal complication in critically ill patients. It is generally associated with high propofol doses and/or prolonged propofol administration …

Background PRIS = propofol infusion syndrome Refractory bradycardia and cardiovascular collapse Poorly understood mechanism Risk factors High doses of (> 4mg/kg/hr or 67 mcg/kg/min) Long …