Smads (or SMADs) comprise a family of structurally similar proteins that are the main signal transducers for receptors of the transforming growth factor beta (TGF-B) superfamily, which are critically …

With in-depth studies on the TGF-β pathway and SMAD proteins, SMAD proteins are expected to become important biomarkers for breast cancer diagnosis and provide therapeutic targets for breast …

SMAD proteins are vertebrate proteins, products of the Sma and Mad genes and represent components of the signal transduction pathway downstream of the serine-threonine kinase receptors. They …

In the nucleus, the SMAD protein complex binds to specific areas of DNA where it controls the activity of particular genes and regulates cell growth and division (proliferation). By controlling these cellular …

Jun 25, 2024 · Smad proteins are integral components of the transforming growth factor-beta (TGF-β) signaling pathway, playing crucial roles in cellular processes such as proliferation, differentiation, and …

Nov 22, 2024 · Of the eight Smad family members in vertebrate, Smad2 and Smad3 are substrates of TGFβ, Nodal and Activin receptors, whereas Smad1, Smad5 and Smad8 are activated by BMP and …

SMAD proteins serve as intracellular mediators of TGFβ signaling, translating extracellular signals into transcriptional responses. They are categorized into three main classes: receptor-regulated SMADs …

Recent progress has shed light into the processes of Smad activation and deactivation, nucleocytoplasmic dynamics, and assembly of transcriptional complexes. A rich repertoire of …

Mar 1, 2024 · Transforming growth factor-β (TGF-β) superfamily and resulting canonical SMAD signaling have gained significant attention in cancer research since the mid-1980s because of their …

Jul 20, 2025 · Smad proteins are a family of transcription factors that act as messengers inside cells. They are responsible for carrying signals from the cell’s surface to the nucleus, which is the cell’s …