In the human brain, tau proteins constitute a family of six isoforms with a range of 352–441 amino acids. Tau isoforms are different in having either zero, one, or two inserts of 29 amino acids at …

We include discussion of other pathologically relevant changes in tau, including mutation and aggregation, and how these aspects impinge on the propensity of tau to propagate, and …

Sep 23, 2025 · Gummy clumps called amyloid plaques have long been the focus of Alzheimer’s therapies. But some Stanford Medicine neuroscientists are focusing on the stringy tangles of a …

Aug 2, 2025 · Tau proteins were first identified in 1975 as heat-stable proteins. Tau proteins play a role in maintaining the internal framework of healthy brain cells. Their primary function …

Mar 5, 2025 · The neurotransmitter glutamate is essential for regulating everything from mood to memory, but it can also encourage a toxic buildup of the notorious tau protein, which can …

Tau protein levels have become a pivotal focus in the study of brain health and neurodegenerative diseases. These proteins play an essential role in maintaining the structure …

Researchers are exploring ways to more precisely target and remove tau from the brain, in particular tau proteins that are found outside of neurons, which are a major cause of disease …

May 14, 2025 · Tau is a flexible protein that stabilizes the internal structure of neurons and supports intracellular transport. 1 When dysregulated, tau becomes prone to misfolding and …

5 days ago · Researchers have identified OTULIN, an immune-regulating enzyme, as a key trigger of tau buildup in the brain. When OTULIN was disabled, tau vanished from neurons and …

May 13, 2025 · Tau protein plays a pivotal role in maintaining neuronal structure and function through its regulation of microtubule stability and neuronal polarity. Encoded by the MAPT …