The fission yeast mutant wee1, also called wee1−, divides at a significantly smaller cell size than wildtype cells. Since Wee1 inhibits entry into mitosis, its absence will lead to division at a …

Wee1 is the principal gatekeeper for both G2/M and S-phase checkpoints, where it plays a key role in cell cycle regulation and DNA damage repair.

Jul 1, 2025 · This review explores WEE1’s biological functions, its role in drug resistance and immune modulation, and strategies to enhance WEE1 inhibition in cancer therapy.

Nov 14, 2025 · WEE1 (WEE1 G2 Checkpoint Kinase) is a Protein Coding gene. Diseases associated with WEE1 include Breast Cancer and Glioma Susceptibility 1. Among its related …

Mar 7, 2024 · Here, the authors perform a multi-omics analysis of hyperthermia-treated ovarian cancer cells, show that CDK1 becomes hyperactivated and regulates signalling upon …

Wee1 is a tyrosine kinase that inhibits the activation of CDK1 and CDK2 to protect genomic integrity by regulating initiation of replication.

This review summarises WEE1 involvement in the cell cycle checkpoints, epigenetic modification and immune signalling, as well as the current state of WEE1 inhibitors in cancer therapeutics.

Jun 3, 2023 · WEE1 is a checkpoint kinase critical for mitotic events, especially in cell maturation and DNA repair. Most cancer cells’ progression and survival are linked with elevated levels of …

Jan 12, 2023 · The cell-cycle checkpoint kinase WEE1 is emerging as a therapeutic target for cancer treatment.

Jan 17, 2024 · WEE1 is a crucial kinase involved in the regulation of G2/M checkpoint within the cell cycle. This article aims to comprehensively review the existing knowledge on the …