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Antigen-Presenting Cells (APCs) like dendritic cells, macrophages, and B cells activate T cells by processing foreign pathogens into peptide fragments, displaying them on their surface bound to Major Histocompatibility Complex (MHC) molecules (Signal 1), and providing co-stimulatory signals (Signal 2). This dual signaling through the T Cell Receptor (TCR) binding the peptide-MHC complex and co-stimulatory molecules (like B7 on APCs binding CD28 on T cells) triggers T cell proliferation and diffe
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