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🧠 How Could Joints and Muscles Feel “Inflamed” Without Exercise? From a research perspective, it’s not always about physical damage. Chronic physiological stress can overactivate an enzyme called CD38, which rapidly consumes NAD⁺—a molecule essential for cellular repair, mitochondrial function, and inflammatory balance. When NAD⁺ availability drops, tissues lose the metabolic capacity to fully resolve low-grade inflammatory signals. The result can feel like unexplained joint achiness or muscle
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