The ONE time we use Oral Vancomycin! We associate Vancomycin with IV infusions for MRSA. But for Clostridium difficile (C. diff) colitis, the rules flip. 🔄 Why Oral? Vancomycin has poor oral bioavailability. It is not absorbed into the bloodstream. For Systemic Infections: This is bad (useless orally). For C. diff Colitis: This is PERFECT! The drug stays in the gut lumen, achieving high local concentrations exactly where the bacteria are. Why NOT IV? IV Vancomycin does not secrete well into the
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