MSN
MSN
Jul 6, 2023
MSN
The controversy surrounding Hormone Replacement Therapy (HRT) escalated primarily due to findings from the Women’s Health Initiative (WHI) study, a large-scale research effort launched in the early 2000s. Initially intended to assess the long-term benefits of HRT in postmenopausal women, the WHI unexpectedly reported concerning outcomes related to certain types of hormone therapy. Specifically, the study suggested that a combination of conjugated equine estrogen (Premarin) and medroxyprogesteron
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Premarin is a combination of estrogens, some which activate the estrogen receptor, and others which act like SERMS (Selective Estimrogen Receptor Modulator) which can actually block certain estrogen receptors. It has been shown to reduce the risk of breast cancer by 22% when Premarin was used ALONE (not combined with progesterone). This effect was not seen when progesterone (Provera) was added. It also has not been demonstrated with estradiol (what you get in your patch). #estradiol #estrogen #m
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